COLLABORATORS AT BEATA MARIA HOSPITAL (HOSPITAL BEATA MARIA)

Marcos Ríos Neuropsychologist
Ana Bravo Internal Medicine specialist
Paulina Oliva Rehabilitation specialist
Paloma Fernandez Physiotherapist

EXTERNAL COLLABORATORS:

Computational Biophysics Group UFV
Neural and Cognitive Engineering Group (GNEC)
12 de Octubre Hospital (Hospital 12 de Octubre) Neuroscience Group
Laboratory of Medical Imagining and biometric analysis (LAMBIO)

STUDENTS

PRE-DOCTORAL STUDENTS (TFG)
Olivia Romera (2020)
Janet Fernández (2020)
Antonio Pérez (2020)
Pablo Espáriz (2019)
Macarena Casas (2018)
Rosa García (2018)

GRADUATED STUDENTS
Jorge Andreo (2017-2019) (Master)
Alfredo Traba (2015-2018) (Thesis)

LINES OF INVESTIGATION

• >Neurorehabilitation of the motor and non-motor symptoms of Parkinson’s Disease
• >Neurorehabilitation of motor and cognitive sequelae of acquired brain injury

SUMMARY OF RESEARCH:

The group’s goal is to develop a line covering neurorehabilitation of neurological diseases using the most advanced technology avaliable. Our research is based on clinical and therapeutic needs that are solved in collaboration with groups such as robotic engineering (GNEC- CSIC) engineers or experts in image processing ( URJC).

The most ambitious project that has launched the group is oriented towards the non-invasive neuromodulation for neurorehabilitation, in this case in Parkinson’s disease and in the future hopes to expand to brain damage.

The brain modulation refers to changing the electrical and functional behavior of neural networks that are altered, enhancing their normal operation. In this phase we will use two approaches to achieve this modulation and restoration of motor functions.

transcranial magnetic stimulation, which seeks to change the excitability of the cerebral cortex using externally applied electromagnetic energy, without causing any discomfort to the patient. Neuromodulation will be complemented by the use of immersive 3D system that will allow the patient to “retrain” their movements at home to prolong the effects of neuromodulation received at the hospital. The purpose is to make available to patients an effective technique and noninvasive hospital level (magnetic stimulation) which can be complemented with neurofeedback you can do comfortably at home reducing health costs, improving their well-being and potentially reducing their requirement for medication.

This activity puts our university on the map of clinical research in Neurology and enables us to form links with numerous research groups dedicated to this type of neurophysiological research around the world. The research of cortical neurophysiology has been one of the Hot Topics on Neurology in recent years.

The group is open to collaborations of students, professors and other researchers inside and outside the university interested in this field.

PUBLICATIONS

Gurdiel-Álvarez F, González-Zamorano Y, Lerma Lara S, Gómez-Soriano J, Taylor J, Romero JP, et al. Effectiveness of Unihemispheric Concurrent Dual-Site Stimulation over M1 and Dorsolateral Prefrontal Cortex Stimulation on Pain Processing: A Triple Blind Cross-Over Control Trial. Brain Sciences. febrero de 2021;11(2):188.

Arroyo-Ferrer A, Sánchez-Cuesta FJ, González-Zamorano Y, Del Castillo MD, Sastre-Barrios C, Ríos-Lago M, et al. Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson’s Disease: Study Protocol for a Randomized Controlled Trial. Medicina (Kaunas). 26 de marzo de 2021;57(4).

Romero JP, Bravo-Martín A, Oliva-Navarrete P, Sánchez-Cuesta F, Ríos-Lago M, Benito-León J. Impact of COVID-19 on a brain damage unit. Diabetes & Metabolic Syndrome: Clinical Research & Reviews [Internet]. 6 de junio de 2021 [citado 7 de junio de 2021]; Disponible en: https://www.sciencedirect.com/science/article/pii/S1871402121001818

Aida Arroyo-Ferrer D de N, Aida Arroyo-Ferrer D de N. Cognitive rehabilitation in a case of traumatic brain injury using EEG-based neurofeedback in comparison to conventional methods. Journal of Integrative Neuroscience. 30 de junio de 2021;20(2):449-57.

Arroyo-Ferrer A, Andreo J, Periáñez JA, Ríos-Lago M, Lubrini G, Herreros-Rodríguez J, et al. Computerized Simple Reaction Time and Balance in Nondemented Parkinson’s Patients. NDD. 16 de julio de 2021;1-7.

Sánchez-Cuesta FJ, Arroyo-Ferrer A, González-Zamorano Y, Vourvopoulos A, Badia SB i, Figuereido P, et al. Clinical Effects of Immersive Multimodal BCI-VR Training after Bilateral Neuromodulation with rTMS on Upper Limb Motor Recovery after Stroke. A Study Protocol for a Randomized Controlled Trial. Medicina. agosto de 2021;57(8):736.

Maitín AM, García-Tejedor AJ, Muñoz JPR. Machine Learning Approaches for Detecting Parkinson’s Disease from EEG Analysis: A Systematic Review. Applied Sciences. enero de 2020;10(23):8662.

González-Zamorano Y, Fernández-Carnero J, Sánchez-Cuesta FJ, Arroyo-Ferrer A, Vourvopoulos A, Figueiredo P, et al. New Approaches Based on Non-Invasive Brain Stimulation and Mental Representation Techniques Targeting Pain in Parkinson’s Disease Patients: Two Study Protocols for Two Randomized Controlled Trials. Brain Sciences. enero de 2021;11(1):65.

Maitín AM, Perezzan R, Herráez-Aguilar D, Serrano JI, Del Castillo MD, Arroyo A, et al. Time Series Analysis Applied to EEG Shows Increased Global Connectivity during Motor Activation Detected in PD Patients Compared to Controls. Applied Sciences. enero de 2021;11(1):15.

Arroyo A, Periáñez JA, Ríos‐Lago M, Lubrini G, Andreo J, Benito‐León J, et al. Components determining the slowness of information processing in parkinson’s disease. Brain and Behavior. 2021 (n/a):e02031.

Benito-León, Julián, Elan D. Louis, Eva Manzanedo, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, José Antonio Molina-Arjona, Michele Matarazzo, et al. «Resting State Functional MRI Reveals Abnormal Network Connectivity in Orthostatic Tremor». Medicine 95, n.^o 29 (julio de 2016): e4310. https://doi.org/10.1097/MD.0000000000004310.

Benito-León, Julián, Elan D. Louis, Virginia Mato-Abad, Ulrike Dydak, Juan Álvarez-Linera, Juan Antonio Hernández-Tamames, José Antonio Molina-Arjona, et al. «In Vivo Neurometabolic Profiling in Orthostatic Tremor». Medicine 95, n.^o 37 (septiembre de 2016): e4848. https://doi.org/10.1097/MD.0000000000004848.

Benito-León, Julián, Elan D. Louis, Virginia Mato-Abad, Alvaro Sánchez-Ferro, Juan P. Romero, Michele Matarazzo, y J. Ignacio Serrano. «A Data Mining Approach for Classification of Orthostatic and Essential Tremor Based on MRI-Derived Brain Volume and Cortical Thickness». Annals of Clinical and Translational Neurology 6, n.^o 12 (diciembre de 2019): 2531-43. https://doi.org/10.1002/acn3.50947.

Benito-León, Julián, Elan D. Louis, Verónica Puertas-Martín, Juan Pablo Romero, Michele Matarazzo, José Antonio Molina-Arjona, Cristina Domínguez-González, y Álvaro Sánchez-Ferro. «Cognitive and Neuropsychiatric Features of Orthostatic Tremor: A Case-Control Comparison». Journal of the Neurological Sciences 361 (15 de febrero de 2016): 137-43. https://doi.org/10.1016/j.jns.2015.12.031.

Benito-León, Julián, Elan D. Louis, Juan Pablo Romero, Juan Antonio Hernández-Tamames, Eva Manzanedo, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ignacio Posada, y Eduardo Rocon. «Altered Functional Connectivity in Essential Tremor: A Resting-State FMRI Study». Medicine 94, n.^o 49 (diciembre de 2015): e1936. https://doi.org/10.1097/MD.0000000000001936.

Benito-León, Julián, Virginia Mato-Abad, Elan D. Louis, Juan Antonio Hernández-Tamames, Juan Álvarez-Linera, Félix Bermejo-Pareja, Ángela Domingo-Santos, Luis Collado, y Juan Pablo Romero. «Author Correction: White Matter Microstructural Changes Are Related to Cognitive Dysfunction in Essential Tremor». Scientific Reports 8, n.^o 1 (6 de marzo de 2018): 4301. https://doi.org/10.1038/s41598-018-22516-1.

«White matter microstructural changes are related to cognitive dysfunction in essential tremor». Scientific Reports 7 (7 de junio de 2017). https://doi.org/10.1038/s41598-017-02596-1.

Benito‐León, Julián, Juan P. Romero, Elan D. Louis, Alvaro Sánchez‐Ferro, Michele Matarazzo, José A. Molina‐Arjona, y Virginia Mato‐Abad. «Diffusion Tensor Imaging in Orthostatic Tremor: A Tract-Based Spatial Statistics Study». Annals of Clinical and Translational Neurology 6, n.^o 11 (2019): 2212-22. https://doi.org/10.1002/acn3.50916.

Benito-León, Julián, Juan P. Romero, Elan D. Louis, Alvaro Sánchez-Ferro, Michele Matarazzo, José A. Molina-Arjona, y Virginia Mato-Abad. «Diffusion Tensor Imaging in Orthostatic Tremor: A Tract-Based Spatial Statistics Study». Annals of Clinical and Translational Neurology 6, n.^o 11 (noviembre de 2019): 2212-22. https://doi.org/10.1002/acn3.50916.

Benito-León, Julián, Emilio Sanz-Morales, Helena Melero, Elan D. Louis, Juan P. Romero, Eduardo Rocon, y Norberto Malpica. «Graph Theory Analysis of Resting-State Functional Magnetic Resonance Imaging in Essential Tremor». Human Brain Mapping 40, n.^o 16 (01 de 2019): 4686-4702. https://doi.org/10.1002/hbm.24730.

«Graph Theory Analysis of Resting-State Functional Magnetic Resonance Imaging in Essential Tremor». Human Brain Mapping, 22 de julio de 2019. https://doi.org/10.1002/hbm.24730.

Benito-León, Julián, J. Ignacio Serrano, Elan D. Louis, Ales Holobar, Juan P. Romero, P. Povalej-Bržan, Félix Bermejo-Pareja, M. Dolores Del Castillo, Ignacio J. Posada, y Eduardo Rocon. «Tremor Severity in Parkinson’s Disease and Cortical Changes of Areas Controlling Movement Sequencing: A Preliminary Study». Journal of Neuroscience Research, 16 de abril de 2018. https://doi.org/10.1002/jnr.24248.

Benito‐León, Julián, José Ignacio Serrano, Elan D. Louis, Ales Holobar, Juan P. Romero, Petra Povalej‐Bržan, Jernej Kranjec, et al. «Essential Tremor Severity and Anatomical Changes in Brain Areas Controlling Movement Sequencing». Annals of Clinical and Translational Neurology 0, n.^o 0 (s. f.). https://doi.org/10.1002/acn3.681.

Gallego, Juan A., Jakob L. Dideriksen, Ales Holobar, Jaime Ibáñez, Vojko Glaser, Juan P. Romero, Julián Benito-León, José L. Pons, Eduardo Rocon, y Dario Farina. «The Phase Difference Between Neural Drives to Antagonist Muscles in Essential Tremor Is Associated with the Relative Strength of Supraspinal and Afferent Input». The Journal of Neuroscience: The Official Journal of the Society for Neuroscience 35, n.^o 23 (10 de junio de 2015): 8925-37. https://doi.org/10.1523/JNEUROSCI.0106-15.2015.

Holobar, Aleš, Juan A. Gallego, Jernej Kranjec, Eduardo Rocon, Juan P. Romero, Julián Benito-León, José L. Pons, y Vojko Glaser. «Motor Unit-Driven Identification of Pathological Tremor in Electroencephalograms». Frontiers in Neurology 9 (29 de octubre de 2018). https://doi.org/10.3389/fneur.2018.00879.

López-Blanco, R., J. Benito-León, S. Llamas-Velasco, M. D. Del Castillo, J. I. Serrano, E. Rocon, J. P. Romero, y M. A. Velasco. «Interaction with Touchscreen Smartphones in Patients with Essential Tremor and Healthy Individuals». Neurologia (Barcelona, Spain), 10 de agosto de 2018. https://doi.org/10.1016/j.nrl.2018.05.005.

López-Blanco, Roberto, Miguel A. Velasco, Antonio Méndez-Guerrero, Juan Pablo Romero, María Dolores Del Castillo, J. Ignacio Serrano, Julián Benito-León, Félix Bermejo-Pareja, y Eduardo Rocon. «Essential Tremor Quantification Based on the Combined Use of a Smartphone and a Smartwatch: The NetMD Study». Journal of Neuroscience Methods, 23 de febrero de 2018. https://doi.org/10.1016/j.jneumeth.2018.02.015.

López-Blanco, Roberto, Miguel A. Velasco, Antonio Méndez-Guerrero, Juan Pablo Romero, María Dolores Del Castillo, J. Ignacio Serrano, Eduardo Rocon, y Julián Benito-León. «Smartwatch for the Analysis of Rest Tremor in Patients with Parkinson’s Disease». Journal of the Neurological Sciences 401 (15 de junio de 2019): 37-42. https://doi.org/10.1016/j.jns.2019.04.011.

Puertas-Martín, Verónica, Alberto Villarejo-Galende, Sara Fernández-Guinea, Juan Pablo Romero, Elan D. Louis, y Julián Benito-León. «A Comparison Study of Cognitive and Neuropsychiatric Features of Essential Tremor and Parkinson’s Disease». Tremor and Other Hyperkinetic Movements 6 (15 de diciembre de 2016). https://doi.org/10.7916/D86H4HRN.

Serrano, J. Ignacio, María Dolores del Castillo, Verónica Cortés, Nuno Mendes, Aida Arroyo, Jorge Andreo, Eduardo Rocon, María del Valle, Jaime Herreros, y Juan Pablo Romero. «EEG Microstates Change in Response to Increase in Dopaminergic Stimulation in Typical Parkinson’s Disease Patients». Frontiers in Neuroscience 12 (2018). https://doi.org/10.3389/fnins.2018.00714.

Serrano, J. Ignacio, Stefan Lambrecht, M. Dolores del Castillo, Juan P. Romero, Julián Benito-León, y Eduardo Rocon. «Identification of Activities of Daily Living in Tremorous Patients Using Inertial Sensors». Expert Systems with Applications 83 (15 de octubre de 2017): 40-48. https://doi.org/10.1016/j.eswa.2017.04.032.

Serrano, J. Ignacio, Juan P. Romero, Ma Dolores del Castillo, Eduardo Rocon, Elan D. Louis, y Julián Benito-León. «A data mining approach using cortical thickness for diagnosis and characterization of essential tremor». Scientific Reports 7 (19 de mayo de 2017). https://doi.org/10.1038/s41598-017-02122-3.

Traba, Alfredo, Juan Pablo Romero, Beatriz Arranz, y Concepción Vilela. «A New Criterion for Detection of Radiculopathy Based on Motor Evoked Potentials and Intraoperative Nerve Root Monitoring». Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology 129, n.^o 10 (20 de julio de 2018): 2075-82. https://doi.org/10.1016/j.clinph.2018.07.005.

CURRENT RESEARCH PROJECTS:

Title: TDCSNeglect Use of direct current transcranial stimulation as an adjunctive therapy in the rehabilitation of hemineglect in stroke

Funding agency: Universidad Francisco de Vitoria (Proyecto Interno Competitivo) Convocatoria 2020

Period: 2 años.

Collaborators:

Cognitive Neurolab. Universidad Oberta de Catalunya http://cognitiveneurolab.org/

Unidad de Daño Cerebral del Hospital Beata María Ana. Madrid.

 

Title: HandBoost. Use of repetitive transcranial magnetic stimulation as adjuvant therapy in upper limb rehabilitation in cortical ischemic stroke

Funding agency: Universidad Francisco de Vitoria (Proyecto Interno Competitivo) Convocatoria 2019

Period: 2 años.

Collaborators:

Grupo de Ingeniería Neural y Cognitiva CSIC. https://g-nec.car.upm-csic.es/

Unidad de Daño Cerebral del Hospital Beata María Ana. Madrid.

 

Title: Balanc-EP: Processing speed as an evolution marker in Parkinson’s disease and associated balance disturbances.

Funding agency: Asociación Madrileña de Neurología (Proyecto Competitivo) Convocatoria 2019

Period: 1 año.

Collaborators:

Unidad de Daño Cerebral del Hospital Beata María Ana. Madrid.

  

Title: ExoMI. Evaluation of a gait rehabilitation and support system for people with lower limb motor sequelae secondary to acquired brain damage.

Funding agency: Sin financiación

Period: 3 años.

Collaborators: Grupo de Ingeniería Neural y Cognitiva CSIC. https://g-nec.car.upm-csic.es/

Unidad de Daño Cerebral del Hospital Beata María Ana. Madrid.

 

Title: EntroPark. Entropy in the electroencephalographic record as a severity marker of Parkinson’s disease and neuropsychological correlate

Funding agency: Sin financiación

Period: 3 años.

Collaborators: Centro de Innovación Experimental del Conocimiento UFV https://www.slash-env.com/investigacion-ufv/ceiec/

OTHER PROJECTS (last 5 years):

Title: NeuroMOD Development and clinical validation of a neuromodulation-based rehabilitation platform for patients with motor control disorders

Funding agency: Ministerio de Economía. Proyectos Retos de la Sociedad 2015

Period: 3 años.